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By H.-L. Krüskemper (Auth.)

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A n o t h e r possibility of interpretation is the analysis of the graphic 37 ACTIVITIES representation of the m e a s u r e d values as shown in Fig. 14. This illustration is intended to display the therapeutic range of an anapropionate - 500 - 500 - 500 en 500 Sem. o en Lev. ves. o , mg/IOOgm . 500 ani mg/IOOgm en . o . 001 mg weight F I G . 14. T h e influence of anabolic steroids in a variety of dosages on the weight of seminal vesicles and levator ani muscle of castrated rats [ G . K. S u c h o w s k y and K.

6. 7. 8. 9. 10. 11. 12. 13. 14. 15. {\\ 65)]. Of all the anabolic steroids, only 1 -methyl- 17/3-hydroxy-5a: androst-1 -en-3-one (methenolone), 17a-methyl-17/3-hydroxyandrosta-l,4-dien-3-one (methandrostenolone), a n d the 19-norsteroids already discussed h a v e been tested for the possibility of aromatization. T h e investigations of R y a n (185) suggest that 17/3h y d r o x y a n d r o s t a - l , 4 - d i e n - 3 - o n e is aromatized to a m e a s u r a b l e extent by the placental e n z y m e system (cf.

In other w o r d s , the absolute influence of anabolic steroids on nitrogen excretion in the urine lessens with a decreasing protein c o n t e n t of the diet (269). By the s a m e token, the nitrogen-retaining effect of anabolic steroids c a n n o t be potentiated indefinitely with an increase of the ACTIVITIES 49 protein content in the diet. 4% to 2 7 . 5 % and 4 2 . 4% protein c o n t e n t of the diet (250). Following the publications of Kochakian, investigations in the h u m a n being reveal the same relationship b e t w e e n nitrogen balance and androgen administration.

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