By Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann
Detailing the most recent protocols for getting to know animal types of diabetes, in particular resistant teams of rodents resembling the NOD mouse, and together with professional suggestion on implementation, this can be a important new quantity within the tools in Molecular Biology sequence.
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Detailing the newest protocols for studying animal versions of diabetes, specially resistant teams of rodents comparable to the NOD mouse, and together with specialist suggestion on implementation, this can be a worthy new quantity within the tools in Molecular Biology sequence.
Additional info for Animal Models in Diabetes Research
The immunomodulatory drug FTY720 can prevent autoimmune diabetes in Treg depleted BBDR rats if administered before and/or during stimulation and expansion of the autoreactive T cells or in the early stages of insulitis (94). 1AR1-iddm rat (95). 1AR1-iddm rat (73, 87, 95, 96). Recent genetic studies suggest that a key diabetes 40 R. Bortell and C. Yang susceptibility locus in the BB and other diabetes-susceptible rat strains is an allele of the TCR Vbeta chain (97), raising the possibility that specific TCR alleles in humans may one day be associated with disease susceptibility.
Am J Physiol Endocrinol Metab 293:E1687–1696 Chapter 3 The BB Rat as a Model of Human Type 1 Diabetes Rita Bortell and Chaoxing Yang Abstract The BB rat is an important rodent model of human type 1 diabetes (T1D) and has been used to study mechanisms of diabetes pathogenesis as well as to investigate potential intervention therapies for clinical trials. The Diabetes-Prone BB (BBDP) rat spontaneously develops autoimmune T1D between 50 and 90 days of age. The Diabetes-Resistant BB (BBDR) rat has similar diabetes-susceptible genes as the BBDP, but does not become diabetic in viral antibody-free conditions.
One recent study by Kruger et al. utilized the virus-inducible BBDR rat model to evaluate the therapeutic value of the adipokine, leptin, when given at three different stages of diabetes (62). High doses of leptin (given as a pre-treatment) prevented insulitis and diabetes in >90% of rats treated with the combination of KRV and poly I:C. In new onset diabetic rats, leptin treatment prevented rapid weight loss and diabetic ketoacidosis, and temporarily restored euglycemia. In addition, leptin treatment was also found to prevent autoimmune recurrence in diabetic rats transplanted with syngeneic islets (62).