By Shi Wei
Bone is a dwelling tissue at risk of strengthen a various array of inflammatory, metabolic, genetic, reactive, circulatory and neoplastic abnormalities. The Atlas of Bone Pathology describes and selectively illustrates the traditional and pathologic stipulations that afflict human bone, focusing seriously on tumor and tumor-like stipulations of bone and their non-neoplastic mimics. Supplemented with radiographic and designated learn pictures, this awesome choice of top of the range electronic photos relief carrying on with efforts to acknowledge, comprehend, and properly interpret the sunshine microscopic findings in bone specimens.
Authored via nationally and across the world famous pathologists, The Atlas of Bone Pathology is a concise and resource for either amateur and professional pathologists alike.
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In this lesion, the cartilage often undergoes endochondral ossification. Note the irregular islets of cartilage. The abundant spicules of osteoid rimmed by plump osteoblasts on the left may result in confusion with chondroblastic osteosarcoma Fig. 28 Chest wall hamartoma. Longstanding lesions typically have mature bone formation 17 18 Fig. 29 Chest wall hamartoma. The solid cartilage components may have intermixed cystic areas filled with blood, thereby resembling an aneurysmal bone cyst Fig. 30 Chest wall hamartoma.
25 Aggressive osteoblastoma. Histologic appearance of the lesion seen in Fig. 22. 3 Osteoblastoma Fig. 26 Aggressive osteoblastoma. A high-magnification view exhibits a sheet-like growth pattern of “epithelioid osteoblasts” characterized by eccentrically positioned, round-to-oval vesicular nuclei containing a single nucleolus and an abundantly clear or finely granular eosinophilic cytoplasm. Mitoses may be discernible, but atypical forms are not present. It should be noted that there is continuing debate in the literature as to whether these lesions represent benign, locally aggressive, or early but fully transformed (osteosarcoma) tumors.
The radiographic features of osteoblastoma may be specific but more commonly are not, and they may have features suggestive of a malignancy. The margins may be well-demarcated, poorly defined, or indefinite. An osteoblastoma usually does not induce a marked periosteal reaction, as illustrated in this case 30 Fig. 14 Osteoblastoma. Magnetic resonance (MR) images of the lesion shown in Fig. 13. The subchondral epiphyseal lesion is isointense to the adjacent muscle on a T1-weighted sequence (left), with a multilocular brighter and heterogeneous T2 signal (right).