Download Biomaterials and medical tribology: Research and development by J Paulo Davim PDF

By J Paulo Davim

Medical tribology will be outlined because the technology of tribological phenomena within the human physique, either those who obviously happen within the tissues or organs and people who come up after implantation of a man-made machine, whereas biomaterials are inert elements designed to be integrated into dwelling structures. The editor, J. Paulo Davim, brings jointly a suite of top of the range articles and case reports concentrating on new learn and advancements in those vital fields of scientific tribology and biomaterials. Contributions offer information of the different sorts of biomaterials, together with metals, polymers and composites and supply an research of friction, put on, lubrication and different comparable matters in particular applications.

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Ii) Active targeting, which involves the use of peripherally conjugated targeting moieties for enhanced delivery of nanoparticle systems. Nowadays, chemotherapy is widely used in cancer treatment. Paclitaxel, cisplatin, carboplatin, doxorubicin (DOX), decitabine or their combinations are considered as first-line chemotherapeutic agents for various cancers. The lack of specificity and poor pharmaco-bioavailability exhibited by the chemotherapeutic agents provoke toxicity, major side-effects and cancer recurrence due to tumor resistance to the chemotherapeutic agents.

Therefore, the conjugation of Au nanoparticles with antibiotics in combination with some type of targeting would be a possible way to improve antibiotic efficacy. Au nanoparticles can be 20 Published by Woodhead Publishing Limited, 2013 Nanoparticles for biomedical applications directly conjugated with antibiotics or other drug molecules via ionic or covalent bonding, or by physical absorption. , 2007). 4a). MTX is an analog of folic acid that has the ability to destroy folate metabolism of cells and has been commonly used as a cytotoxic anticancer drug.

TEM images showed that the shapes remaining after irradiation at 1100 nm were short rods, spheres and a ‘candywrap’ shape. They further studied the selective release of two DNAs, FAM-DNA and TMR-DNA, in the mixture of short and long Au nanorods, respectively. After laser irradiation at a wavelength of 800 nm, about 70% of the FAM-DNA attached to the short rods was released while only about 10% of the TMR-DNA conjugated to long rods was released. 5). Gold nanoparticles as a heat source Au nanoparticles absorb light millions of times more strongly than organic dye molecules.

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