By Thomas M. Santella, David J. Triggle
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45 46 BODY ENHANCEMENT PRODUCTS Mechanism of Action: hGH Human growth hormone is a protein hormone normally synthesized by the pituitary gland. It is a continuous chain of 191 amino acids. hGH has both direct and indirect effects on the body. hGH directly affects the production of skin, muscle, and bone cells by targeting specific hormone receptors in each and instructing cells to reproduce. It also targets and breaks down fat cells, which stimulates a person’s overall metabolism. In addition, hGH indirectly affects growth by signaling the liver to produce insulin-like growth factor-1 (IGF-1).
For example, Lance Armstrong,6 the champion bicyclist, has a heart that is larger than average and is therefore able to pump more oxygen-rich blood throughout his body. The efficiency of the oxygen system is 49 50 BODY ENHANCEMENT PRODUCTS increased naturally through exercise, but modern athletes are using techniques and drugs that artificially boost RBC levels in the hope of achieving heightened endurance levels. TYPES OF BLOOD DOPING Perhaps the simplest form of blood doping is breathing pure oxygen.
Liver damage and jaundice. Source: Voy, Robert, and Kirk D. Deeter. Drugs, Sport, and Politics. Champaign, IL: Human Kinetics Publishers, 1991, p. 24. 41 42 BODY ENHANCEMENT PRODUCTS forms, because products that pass through the stomach are directly filtered by the liver. Cardiovascular Problems Research has indicated that one of the long-term effects of AAS use is lower levels of high-density lipoprotein (HDL) cholesterol (good cholesterol), which helps keep arteries clear. Reductions in HDL cholesterol levels can lead to increased buildup of materials in the blood vessels (plaques), which in turn can result in a variety of heart and vascular problems, such as high blood pressure, atherosclerosis, and heart attack.